Record Details

Role of Transport and Kinetics in Growth of Renal Stones
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Author and Affiliation:
Kassemi, Mohammad(National Center for Space Exploration Research on Fluids and Combustion, Cleveland, OH, United States);
Iskovitz, Ilana(National Center for Space Exploration Research on Fluids and Combustion, Cleveland, OH, United States)
Abstract: Renal stone disease is not only a concern on earth but could conceivably pose as a serious risk to the astronauts health and safety in Space. In this paper, a combined transport-kinetics model for growth of calcium oxalate crystals is presented. The model is used to parametrically investigate the growth of renal calculi in urine with a focus on the coupled effects of transport and surface reaction on the ionic concentrations at the surface of the crystal and their impact on the resulting growth rates. It is shown that under nominal conditions of low solution supersaturation and low Damkohler number that typically exist on Earth, the surface concentrations of calcium and oxalate approach their bulk solution values in the urine and the growth rate is most likely limited by the surface reaction kinetics. But for higher solution supersaturations and larger Damkohler numbers that may be prevalent in the microgravity environment of Space, the calcium and oxalate surface concentrations tend to shift more towards their equilibrium or saturation values and thus the growth process may be limited by the transport through the medium. Furthermore, parametric numerical studies suggest that changes to the renal biochemistry of astronauts due in space may promote development of renal calculi during long duration space expeditions.
Publication Date: Jul 16, 2012
Document ID:
20130011628
(Acquired Mar 29, 2013)
Subject Category: AEROSPACE MEDICINE
Report/Patent Number: GRC-E-DAA-TN5626
Document Type: Oral/Visual Presentation
Meeting Information: AIAA 42nd International Conference on Environmental Systems (ICES) Conference; 15-19 Jul. 2012; San Diego, CA; United States
Meeting Sponsor: American Inst. of Aeronautics and Astronautics; Washington, DC, United States
Contract/Grant/Task Num: NNC08BA05B; NNC08BA08B; WBS 444543.01.02.01.06
Financial Sponsor: NASA Glenn Research Center; Cleveland, OH, United States
Organization Source: National Center for Space Exploration Research on Fluids and Combustion; Cleveland, OH, United States
Description: 19p; In English; Original contains color and black and white illustrations
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright; Distribution under U.S. Government purpose rights; under NASA contracts NNC08BA05B and NNC08BA08B
NASA Terms: KINETICS; URINE; KIDNEY STONES; KIDNEY DISEASES; AEROSPACE MEDICINE; MATHEMATICAL MODELS; CALCULI; DAMKOHLER NUMBER; MICROGRAVITY; ASTRONAUTS; LONG DURATION SPACE FLIGHT; BIOCHEMISTRY; TRANSPORT THEORY; RENAL FUNCTION
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